Zerumbone induces growth inhibition of Burkitt’s lymphoma cell line via apoptosis

Zerumbone (ZER), a natural compound has been extracted from Zingiber zerumbet with known pharmacological activities. The aim was to determine the anti-human Burkitt’s lymphoma (Raji) cell effect of ZER. 3-(4,5-dimethylthiazol-2-yl)-2,5,-diphenyltetrazolium bromide (MTT) assay used cytotoxic while Annexin-V-fluorescein isothiocyanate/propidium iodide-PI flow cytometric assays apoptotic ZER on human (ATCC CCL-86) line. expressions Bax, Bcl-2, and c-Myc genes were determined via real-time PCR. suppressed proliferation Raji cells 48 h IC50 value 5.1 μg/mL. Treated also underwent late apoptosis especially after treatment 100 μg/mL is associated increase in Bax decrease Bcl-2 gene expressions. These results suggest that inhibited through modification apoptosis-related Therefore, potential as candidate for lymphoma.